Synthesis of Substituted 5-arylisoxazole derivatives in solvent free condition using ultrasontcation technique

Rajiv V Khobare, Ramkrushna P Pawar, Khandu D Warad, Amit P Tayde,Chandrakant B.Mane


The present work is mainly designed to synthesize A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst using ultrasound technique. The synthesized derivatives were subjected to antibacterial activity. All compounds showed good antibacterial activity. The salient features of this method include simple procedure, mild conditions, no waste produced (only by-product being water), easy purification, moderate to good yields of products and high generality.

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